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Application of concentrated deep sea water inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice

Abstract Background Mineral water from deep-sea bedrock, formed over thousands of years, is rich in minerals such as Ca, Mg, Na, K, Fe and others. Our present study was to investigate the preventive effects of natural deep-sea water on developing atopic dermatitis (AD). Methods We elicited AD by application of DNCB (2,4-dinitro-chlorobezene) in Nc/Nga mouse […]

Application of concentrated deep sea water inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice Read More »

Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice

Abstract In this study, we investigated the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in high-fat diet (HFD)-induced diabetic C57BL/6J mice. BDSW was prepared by mixing deep-sea water (DSW) mineral extracts and desalinated water to give a final hardness of 500–2000. Mice given an HFD with BDSW showed lowered fasting plasma

Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice Read More »

Modulation of glucose metabolism by balanced deep-sea water ameliorates hyperglycemia and pancreatic function in streptozotocin-induced diabetic mice

Abstract The aim of this study was to determine the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in streptozotocin (STZ)-induced diabetic mice. BDSW was prepared by mixing DSW mineral extracts and desalinated water to yield a final hardness of 1000–4000 ppm. Male ICR mice were assigned to 6 groups; mice in

Modulation of glucose metabolism by balanced deep-sea water ameliorates hyperglycemia and pancreatic function in streptozotocin-induced diabetic mice Read More »

Effects of balanced deep-sea water on adipocyte hypertrophy and liver steatosis in high-fat, diet-induced obese mice

Abstract Objective: To determine the effects of balanced deep-sea water (BDSW) on adipocyte hypertrophy and liver steatosis in high-fat diet (HFD)-induced obese C57BL/6J mice. Methods: BDSW was prepared by mixing deep-sea water (DSW) mineral extracts and desalinated water. C57BL/6J mice were fed a normal diet or HFD with or without BDSW with different hardness (500, 1000, or

Effects of balanced deep-sea water on adipocyte hypertrophy and liver steatosis in high-fat, diet-induced obese mice Read More »

Stimulatory effects of balanced deep sea water on mitochondrial biogenesis and function

Abstract The worldwide prevalence of metabolic diseases, including obesity and diabetes, is increasing. Mitochondrial dysfunction is recognized as a core feature of these diseases. Emerging evidence also suggests that defects in mitochondrial biogenesis, number, morphology, fusion, and fission, contribute to the development and progression of metabolic diseases. Our previous studies revealed that balanced deep-sea water

Stimulatory effects of balanced deep sea water on mitochondrial biogenesis and function Read More »

Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice

ABSTRACT Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on

Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice Read More »

Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect.

Abstract When normal rabbits were administered various samples of deep-sea water, their biochemical values changed within normal limits, and no differences from distilled water administration (control) group levels were observed. Furthermore, no histopathological changes were observed in internal organs on the 28th day after administration. The serum total cholesterol (T-Cho) and low density lipoprotein cholesterol

Pharmacological activity of deep-sea water: examination of hyperlipemia prevention and medical treatment effect. Read More »

Effect cholesterol level in plasma of rats by drinking high magnesium water made from deep sea water

Abstract: These results suggest that high magnesium water made from deep sea water may be a useful natural drink to improve lipid metabolism and to prevent of atherosclerosis and coronary artery disease. Read More: Effect of cholesterol level in plasma of rats by drinking high magnesium water made from deep sea water | IEEE Conference

Effect cholesterol level in plasma of rats by drinking high magnesium water made from deep sea water Read More »

Effect of drinking water without salt made from deep sea water in lipid metabolism of rats

Abstract: These results suggest that high magnesium water made from deep sea water may be a useful natural drink to improve lipid metabolism and to prevent of atherosclerosis and coronary artery disease. Read More: Effect of drinking water without salt made from deep sea water in lipid metabolism of rats | IEEE Conference Publication |

Effect of drinking water without salt made from deep sea water in lipid metabolism of rats Read More »